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504275 CB1 antagonist AM251 - CAS 183232-66-8 - Calbiochem

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Synonymes: N-(Piperidin-1-yl)-5-(4-iodophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide, AM 251

Primary Target: CB₁ Receptor
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      Aperçu

      Replacement Information

      Tableau de caractéristiques principal

      CAS #Empirical Formula
      183232-66-8C₂₂H₂₁Cl₂IN₄O
      Description
      OverviewA potent and highly selective antagonist for cannabinoid subtyre 1 (CB1) receptor. Affinity for CB1 (IC50 = 8 nM, Ki = 7.49 nM) is more than 306-fold higher than that for CB2 receptors. Has been used in a study to determine its interaction with hippocampal neurons to enhance spatial memory in mice.
      Catalogue Number504275
      Brand Family Calbiochem®
      SynonymsN-(Piperidin-1-yl)-5-(4-iodophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide, AM 251
      References
      ReferencesGatley, S., et al. 1996. Eur. J. Pharmacol. 307, 331.
      Gatley, S., et al. 1997. Life Sci. 61, 191.
      Lan, R., et al. 1999. J. Med. Chem. 42, 769.
      Pertwee, R., 2005. Life Sci. 76, 1307.
      Ryberg, E., et al. 2007. Br. J. Pharmacol. 152, 1092.
      Assini, F., et al. 2012. Behav. Pharmacol. 23, 292.
      Product Information
      CAS number183232-66-8
      FormWhite solid
      Hill FormulaC₂₂H₂₁Cl₂IN₄O
      Chemical formulaC₂₂H₂₁Cl₂IN₄O
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetCB₁ Receptor
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +15°C to +30°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      504275 0

      Documentation

      CB1 antagonist AM251 - CAS 183232-66-8 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Références bibliographiques

      Aperçu de la référence bibliographique
      Gatley, S., et al. 1996. Eur. J. Pharmacol. 307, 331.
      Gatley, S., et al. 1997. Life Sci. 61, 191.
      Lan, R., et al. 1999. J. Med. Chem. 42, 769.
      Pertwee, R., 2005. Life Sci. 76, 1307.
      Ryberg, E., et al. 2007. Br. J. Pharmacol. 152, 1092.
      Assini, F., et al. 2012. Behav. Pharmacol. 23, 292.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision28-June-2013 JSW
      SynonymsN-(Piperidin-1-yl)-5-(4-iodophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide, AM 251
      DescriptionA potent and highly selective antagonist for cannabinoid subtyre 1 (CB1) receptor. Affinity for CB1 (IC50 = 8 nM, Ki = 7.49 nM) is more than 306-fold higher than that for CB2 receptors. Has been used in a study to determine its interaction with hippocampal neurons to enhance spatial memory in mice.
      FormWhite solid
      CAS number183232-66-8
      Chemical formulaC₂₂H₂₁Cl₂IN₄O
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (10 mg/ml)
      Storage Protect from light
      +15°C to +30°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesGatley, S., et al. 1996. Eur. J. Pharmacol. 307, 331.
      Gatley, S., et al. 1997. Life Sci. 61, 191.
      Lan, R., et al. 1999. J. Med. Chem. 42, 769.
      Pertwee, R., 2005. Life Sci. 76, 1307.
      Ryberg, E., et al. 2007. Br. J. Pharmacol. 152, 1092.
      Assini, F., et al. 2012. Behav. Pharmacol. 23, 292.