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218714 Casein Kinase II Inhibitor IX, IQA - CAS 391670-48-7 - Calbiochem

The Casein Kinase II Inhibitor IV, also referenced under CAS 391670-48-7, controls the biological activity of Casein Kinase II. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: 5-Oxo-5,6-dihydroindolo[1,2-a]quinazoline-7-acetic acid

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      Aperçu

      Replacement Information

      Tableau de caractéristiques principal

      CAS #Empirical Formula
      391670-48-7C₁₇H₁₂N₂O₃
      Description
      OverviewA cell-permeable indoloquinazolinone compound that acts as a potent, selective, reversible CK2 inhibitor (IC50 = 390 nM with 100 µM ATP) in an ATP- and GTP-competitive manner (Ki = 0.17 and 0.21 µM, respectively). IQA exhibits much reduced activity against PI 3-Kα/β/γ (No inhibition at 20 µM) and 48 commonly studied protein kinases (IC50 ≥10 µM with 100 µM ATP) and is more selective than TBB (Cat. Nos. 218697 and 218708) with respect to DYRK1a (IC50 = 8 and <1 µM, respectively, with 100 µM ATP).
      Catalogue Number218714
      Brand Family Calbiochem®
      Synonyms5-Oxo-5,6-dihydroindolo[1,2-a]quinazoline-7-acetic acid
      References
      ReferencesPiazza, F.A., et al. 2006. Blood 108, 1698.
      Di Maira, G., et al. 2005. Cell Death Differ. 12, 668.
      Sarno, S., et al. 2003. Biochem. J. 374, 639.
      Vangrevelinghe, E., et al. 2003. J. Med. Chem. 46, 2656.
      Product Information
      CAS number391670-48-7
      FormLight yellow solid
      Hill FormulaC₁₇H₁₂N₂O₃
      Chemical formulaC₁₇H₁₂N₂O₃
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      S PhraseS: 22-24/25

      Do not breathe dust.
      Avoid contact with skin and eyes.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      218714 0

      Documentation

      Casein Kinase II Inhibitor IX, IQA - CAS 391670-48-7 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Casein Kinase II Inhibitor IX, IQA - CAS 391670-48-7 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      218714

      Références bibliographiques

      Aperçu de la référence bibliographique
      Piazza, F.A., et al. 2006. Blood 108, 1698.
      Di Maira, G., et al. 2005. Cell Death Differ. 12, 668.
      Sarno, S., et al. 2003. Biochem. J. 374, 639.
      Vangrevelinghe, E., et al. 2003. J. Med. Chem. 46, 2656.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision16-August-2017 JSW
      Synonyms5-Oxo-5,6-dihydroindolo[1,2-a]quinazoline-7-acetic acid
      DescriptionA cell-permeable indoloquinazolinone compound that acts as a potent, selective, and reversible CK2 inhibitor (IC50 = 390 nM with 100 µM ATP) in an ATP- and GTP-competitive manner (Ki = 0.17 and 0.21 µM, respectively). IQA exhibits much reduced activity against PI 3-Kα/β/γ (No inhibition at 20 µM) and 48 commonly studied protein kinases (IC50 ≥10 µM with 100 µM ATP) and is more selective than TBB (Cat. Nos. 218697 and 218708) with respect to DYRK1a (IC50 = 8 and <1 µM, respectively, with 100 µM ATP).
      FormLight yellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number391670-48-7
      Chemical formulaC₁₇H₁₂N₂O₃
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (10 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Toxicity Standard Handling
      ReferencesPiazza, F.A., et al. 2006. Blood 108, 1698.
      Di Maira, G., et al. 2005. Cell Death Differ. 12, 668.
      Sarno, S., et al. 2003. Biochem. J. 374, 639.
      Vangrevelinghe, E., et al. 2003. J. Med. Chem. 46, 2656.