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855079 DHP HM resin (100-200 mesh)

Novabiochem®

DHP HM resin (100-200 mesh) : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.
Nº CAS: 9003-70-7
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855079
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Tableau de caractéristiques principal

CAS #
9003-70-7
Description
Référence855079
Replaces01-64-0192
Famille de marques Novabiochem®
Alternate Names
  • 3,4-Dihydro-2H-pyran-2-yl-methoxymethyl polystyrene (100-200 mesh)
  • Ellman's dihydropyran resin
Informations généralesA highly versatile support for the solid phase immobilization of primary, secondary alcohols [1-11], phenols [12], purines [13], and indoles [14]. Derivatization is effected by treating the support in DCM with an excess of alcohol in the presence of a catalytic amount of pyridinium p-toluenesulfonate. A similar DHP-based support has also been used for the immobilization of tetrazoles [15].

Release of the product alcohol from the support has been carried out by treating with 95% TFA/5% water [1] and TFA/DCM/EtOH [2, 12]. However, the use of TFA can lead, in some cases, to trifluoroacetate formation. Methods which eliminate this potential side reaction include PPTS/BuOH/DCE [3], TosOH in DCM [16] and TosOH in DCE/BuOH [17].

The product number for this product was previously 01-64-0192.

To obtain a certificate of analysis (CoA) of a lot that begins with the letter "A", please select the option in the right hand menu "Request a COA for Lot#s starting with A".
Références bibliographiques
Informations produit
Numéro CAS9003-70-7
Code SH3907 29 90
Image de la formule structuraleImage de la formule structurale
Quality LevelMQ200
Applications
Informations biologiques
Informations physico-chimiques
Dimensions
Informations sur les matériaux
Informations toxicologiques
Informations de sécurité selon le SGH
Classe de stockage10 - 13 Autres liquides ou matières solides
WGKWGK 1 pollue faiblement l'eau
Informations sur la sécurité
Notifications sur l'utilisation du produit
Informations relatives au stockage et à l'expédition
StockageConserver de +2°C à +8°C.
Informations sur l'emballage
Informations sur le transport
Information complémentaire
Caractéristiques
Color (visual)slight yellow to beige
Appearance of substance (visual)beads
Loading (determined from the substitution of the Fmoc-Gly-ol loaded resin)0.70 - 1.20 mmol/g
Swelling Volume (in CH₂Cl₂)lot specific result
The polymer matrix is copoly (styrene-1% DVB), 100 - 200 mesh

Documentation

DHP HM resin (100-200 mesh) FDS

Titre

Fiche de données de sécurité des matériaux (FDS) 

Citations

Titre
  • [1] L. A. Thompson & J. A. Ellman (1994) Tetrahedron Lett., 35, 9333.
  • [2] O. B. Wallace (1997) Tetrahedron Lett., 38, 4939.
  • [3] G. Liu & J. A. Ellman (1995) J. Org. Chem., 60, 7712.
  • [4] E. K. Kick & J. A. Ellman (1995) J. Med. Chem., 38, 1427.
  • [5] J. S. Koh & J. A. Ellman (1996) J. Org. Chem., 61, 4494.
  • [6] J. Cossy, et al. (2000) Synlett, 3, 409.
  • [7] M. Ramaseshan, et al. (2000) J. Comb. Chem., 2, 615.
  • [8] M. Ramaseshan, et al. (2000) Tetrahedron Lett., 41, 4743.
  • [9] A. Bianco, et al. (2000) J. Org. Chem., 65, 2179.
  • [10] M. Steger, et al. (2001) Bioorg. Med. Chem. Lett., 11, 2537.
  • [11] A. Dahlgren, et al. (2003) Bioorg. Med.Chem. Lett., 11, 827.
  • [12] W. H. Pearson & R. B. Clark (1997) Tetrahedron Lett., 38, 7669.
  • [13] D. A. Nugiel, et al. (1997) J. Org. Chem., 62, 201.
  • [14] A. L. Smith, et al. (1998) Tetrahedron Lett., 39, 8317.
  • [15] S.-E. Yoo, et al. (1997) Tetrahedron Lett., 38, 1203.
  • [16] J. Beythien (Merck Biociences AG), personal communication.
  • [17] M. R. Tremblay, et al. (1999) Bioorg. Med. Chem. Lett., 9, 2827.