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343020 Flt-3 Inhibitor - CAS 301305-73-7 - Calbiochem

The Flt-3 Inhibitor, also referenced under CAS 301305-73-7, controls the biological activity of Flt-3. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.
Primary Target: Flt-3
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343020
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Aperçu

Replacement Information

Tableau de caractéristiques principal

CAS #Empirical Formula
301305-73-7C₁₈H₂₀N₂O₄S

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343020-5MG
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      		 Ampoule plast. 5 mg
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      Description
      OverviewA cell-permeable thienylcarboxamide compound that acts as a potent, ATP-competitive, and highly selective Flt-3 inhibitor (IC50 = 42 nM) with little effect against a panel of 22 other kinases (IC50 ≥3 µM). Shown to exhibit antiproliferative properties against the human acute myelogenous leukemia cell line MV4-11 (IC50 = 340 nM) expressing constitutively active Flt-3.
      Catalogue Number343020
      Brand Family Calbiochem®
      References
      ReferencesPatch, R.J., et al. 2006. Bioorg. Med. Chem. Lett. 16, 3282.
      Product Information
      CAS number301305-73-7
      ATP CompetitiveY
      FormWhite solid
      Hill FormulaC₁₈H₂₀N₂O₄S
      Chemical formulaC₁₈H₂₀N₂O₄S
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetFlt-3
      Primary Target IC<sub>50</sub>42 nM against Flt-3
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      343020-5MG 04055977195019

      Documentation

      Required Licenses

      Title
      PRODUCTO REGULADO POR LA SECRETARÍA DE SALUD

      Flt-3 Inhibitor - CAS 301305-73-7 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Flt-3 Inhibitor - CAS 301305-73-7 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      343020

      Références bibliographiques

      Aperçu de la référence bibliographique
      Patch, R.J., et al. 2006. Bioorg. Med. Chem. Lett. 16, 3282.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision10-October-2007 JSW
      DescriptionA cell-permeable thienylcarboxamide compound that acts as a potent, ATP-competitive, and highly selective Flt-3 inhibitor (IC50 = 42 nM) with little effect against a panel of 22 other kinases (IC50 ≥3 µM). Shown to exhibit antiproliferative properties against the human acute myelogenous leukemia cell line MV4-11 (IC50 = 340 nM) expressing constitutively active Flt-3.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number301305-73-7
      Chemical formulaC₁₈H₂₀N₂O₄S
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (<4 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Irritant
      ReferencesPatch, R.J., et al. 2006. Bioorg. Med. Chem. Lett. 16, 3282.