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364200 GM 1489

GM 1489 : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: N-[(2R)-2-(Carboxymethyl)-4-methylpentanoyl]-L-tryptophan-(S)-methyl-benzylamide

Primary Target: MMP-1
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      Aperçu

      Replacement Information

      Tableau de caractéristiques principal

      CAS #Empirical Formula
      170905-75-6C₂₇H₃₃N₃O₄
      Description
      Overview

      This product has been discontinued.



      A potent broad-range inhibitor of matrix metalloproteinases (MMPs). Inhibits MMPs in vitro (Ki = 0.2 nM for MMP-1; Ki = 500 nM for MMP-2; Ki = 20 µM for MMP-3; Ki = 100 nM for MMP-8; and Ki = 100 nM for MMP-9). Also reduces the inflammatory and the hyperproliferative responses that occur following topical phorbol ester application.
      Catalogue Number364200
      Brand Family Calbiochem®
      SynonymsN-[(2R)-2-(Carboxymethyl)-4-methylpentanoyl]-L-tryptophan-(S)-methyl-benzylamide
      References
      ReferencesSato, N., et al. 2003. J. Natl. Cancer Inst. 95, 327.
      Holleran, W.M., et al. 1997. Arch. Dermatol. Res. 289, 138.
      Product Information
      CAS number170905-75-6
      ATP CompetitiveN
      FormOff-white solid
      Hill FormulaC₂₇H₃₃N₃O₄
      Chemical formulaC₂₇H₃₃N₃O₄
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetMMP-1
      Primary Target K<sub>i</sub>0.2 nM for MMP-1; 500 nM for MMP-2; 20 µM for MMP-3; 100 nM for MMP-8; 100 nM for MMP-9
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      364200 0

      Documentation

      GM 1489 FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      GM 1489 Certificats d'analyse

      TitreNuméro de lot
      364200

      Références bibliographiques

      Aperçu de la référence bibliographique
      Sato, N., et al. 2003. J. Natl. Cancer Inst. 95, 327.
      Holleran, W.M., et al. 1997. Arch. Dermatol. Res. 289, 138.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision02-July-2008 RFH
      SynonymsN-[(2R)-2-(Carboxymethyl)-4-methylpentanoyl]-L-tryptophan-(S)-methyl-benzylamide
      DescriptionA potent broad-spectrum inhibitor of matrix metalloproteinases (MMPs). Inhibits MMPs in vitro [Ki = 0.2 nM for interstitial collagenase (MMP-1); Ki = 500 nM for gelatinase A (MMP-2); Ki = 20 µM for stromelysin (MMP-3); Ki = 100 nM for neutrophil collagenase (MMP-8); Ki = 100 nM for gelatinase B (MMP-9)]. Also reduces the inflammatory and the hyperproliferative responses that occur following topical phorbol ester application.
      FormOff-white solid
      CAS number170905-75-6
      Chemical formulaC₂₇H₃₃N₃O₄
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (25 mg/ml)
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesSato, N., et al. 2003. J. Natl. Cancer Inst. 95, 327.
      Holleran, W.M., et al. 1997. Arch. Dermatol. Res. 289, 138.