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371724 GPR119 Agonist, AS1269574 - CAS 330981-72-1 - Calbiochem

The GPR119 Agonist, AS1269574, also referenced under CAS 330981-72-1, controls the biological activity of GPR119. This small molecule/inhibitor is primarily used for Biochemicals applications.

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: 2-((2-(4-Bromophenyl)-6-methylpyrimidin-4-yl)amino)ethanol, G-Protein Coupled Receptor 119 Agonist, GPCR2 Agonist, MGC119957 Agonist, SNORF25 Agonist

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371724
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Tableau de caractéristiques principal

CAS #Empirical Formula
330981-72-1C₁₃H₁₄BrN₃O

Prix & Disponibilité

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371724-10MG
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      Description
      OverviewA pyrimidine compound that acts as an effective GPR119 agonist (EC50 = 2.5 µM in stimulating cAMP in hGPR119-expressing HEK293 cells) and reportedly exhibits no activity toward β-adrenergic or GLP-1 receptors. Shown to enhance 16.8 mM glucose-induced insulin secretion from murine MIN-6 β-cells (mU/20 min = 0.44 and 0.22, respectively, with or without 10 µM AS1269574) in vitro and improve glucose tolerance in normal mice (100 mg/kg; p.o.) without any significant hypoglycemic effect in vivo.
      Catalogue Number371724
      Brand Family Calbiochem®
      Synonyms2-((2-(4-Bromophenyl)-6-methylpyrimidin-4-yl)amino)ethanol, G-Protein Coupled Receptor 119 Agonist, GPCR2 Agonist, MGC119957 Agonist, SNORF25 Agonist
      References
      ReferencesYoshida, S., et cl. 2010. Biochem. Biophys. Res. Commun. 400, 437.
      Product Information
      CAS number330981-72-1
      FormAmber solid
      Hill FormulaC₁₃H₁₄BrN₃O
      Chemical formulaC₁₃H₁₄BrN₃O
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥99% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Regulatory Review
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      371724-10MG 04055977213263

      Documentation

      GPR119 Agonist, AS1269574 - CAS 330981-72-1 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      GPR119 Agonist, AS1269574 - CAS 330981-72-1 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      371724

      Références bibliographiques

      Aperçu de la référence bibliographique
      Yoshida, S., et cl. 2010. Biochem. Biophys. Res. Commun. 400, 437.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision24-September-2012 JSW
      Synonyms2-((2-(4-Bromophenyl)-6-methylpyrimidin-4-yl)amino)ethanol, G-Protein Coupled Receptor 119 Agonist, GPCR2 Agonist, MGC119957 Agonist, SNORF25 Agonist
      DescriptionA pyrimidine compound that acts as an effective GPR119 agonist (EC50 = 2.5 µM in stimulating cAMP in hGPR119-expressing HEK293 cells) and reportedly exhibits no activity toward β-adrenergic or GLP-1 receptors. Shown to enhance 16.8 mM glucose-induced insulin secretion from murine MIN-6 β-cells (mU/20 min = 0.22, 0.29, 0.44, respectively, with 0, 1, 10 µM AS1269574) in vitro and improve glucose tolerance in normal mice (26% decrease and 60% increase, respectively, of control blood glucose and insulin AUC0-1h in OGTT; 100 mg/kg; p.o.) without affecting basal blood glucose level in either fed or fasting mice in vivo.
      FormAmber solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number330981-72-1
      Chemical formulaC₁₃H₁₄BrN₃O
      Structure formulaStructure formula
      Purity≥99% by HPLC
      SolubilityDMSO (>10 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Regulatory Review
      ReferencesYoshida, S., et cl. 2010. Biochem. Biophys. Res. Commun. 400, 437.