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531399 IRE1 Inhibitor IV, A-106

A cell permeable compound that specifically targets the RNAse domain of IRE-1 (ERN1) and blocks the activation of X-box binding protein 1 (XBP-1).

IRE1 Inhibitor IV, A-106 : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: ERN1 Inhibitor, A106

Primary Target: IRE1
531399
  
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      Aperçu

      Replacement Information

      Tableau de caractéristiques principal

      Empirical Formula
      C₁₁H₈O₂
      Description
      Overview

      This product has been discontinued.



      A cell permeable naphthaldehyde based compound that specifically targets the RNAse domain of IRE-1 (ERN1) and blocks the activation of X-box binding protein 1 (XBP-1). Shown to be equipotent to its parent compound, STF-083010. Blocks IRE-1 RNase activity via the formation of a stable Schiff base with K907 in the RNase domain of IRE-1, which prevents splicing of XBP-1mRNA. Downregulation of XBP-1 in Em-TCL1 CLL cells leads to apoptosis (~50 to 100 µM). Blocks the proliferation and survival of patient-derived pre-B ALL cells (10 to 50 thousand cells) in sub-lethally irradiated NOD/SCID mice in a dose-dependent manner.

      Please note that the molecular weight for this compound is batch-specific due to variable water content.

      Catalogue Number531399
      Brand Family Calbiochem®
      SynonymsERN1 Inhibitor, A106
      References
      ReferencesKriss, C., et al. 2012. Blood. 120, 1027. Masouleh, B. K., et al. 2014. PNAS. 111, in press.
      Product Information
      FormYellowish-white powder
      Hill FormulaC₁₁H₈O₂
      Chemical formulaC₁₁H₈O₂
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetIRE1
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      531399 0

      Documentation

      IRE1 Inhibitor IV, A-106 FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      IRE1 Inhibitor IV, A-106 Certificats d'analyse

      TitreNuméro de lot
      531399

      Références bibliographiques

      Aperçu de la référence bibliographique
      Kriss, C., et al. 2012. Blood. 120, 1027. Masouleh, B. K., et al. 2014. PNAS. 111, in press.

      Brochure

      Titre
      NPI Flyer- Epigenetics and Nuclear Function Feature
      New Products - Antibodies, Small Molecule, Inhibitors

      Informations techniques

      Titre
      White Paper: Further considerations of antibody validation and usage.