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420146 JAK3 Inhibitor VIII, NSC114792 - CAS 17392-79-9 - Calbiochem

The JAK3 Inhibitor VIII, NSC114792 controls the biological activity of JAK3. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: 10,13-Dimethyl-17-(2-(6-sulfanylidene-3H-purin-9-yl)acetyl)-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one, Dimethyl-sulfanylidene-purinyl-acetyl-dodecahydrocyclopenta[a]phenanthren-3-one

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420146
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Tableau de caractéristiques principal

CAS #Empirical Formula
17392-79-9C₂₆H₃₂N₄O₂S

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      Description
      OverviewA cell-permeable steroidal-purinethione that targets JAK3 kinase domain and selectively inhibits JAK3, but not JAK1, JAK2, or TYK2, activity and effectively blocks the constitutive Jak3 and STAT5 phosphorylations (complete inhibition at 10 µM) in BaF3-JAK3V674A and BLNK-/- BKO84 culltures. Shown to prevent the JAK3-dependent survival of L540, BaF3-JAK3WT, BaF3-JAK3V674A, and BLNK-/- BKO84 cells (by 40%, 50%, 57%, and 85%, respectively; 20 µM; 72 h), while exhibiting no effect against the JAK3-independent growth in DU145, HDLM-2, and MDA-MB-468 cultures.
      Catalogue Number420146
      Brand Family Calbiochem®
      Synonyms10,13-Dimethyl-17-(2-(6-sulfanylidene-3H-purin-9-yl)acetyl)-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one, Dimethyl-sulfanylidene-purinyl-acetyl-dodecahydrocyclopenta[a]phenanthren-3-one
      References
      ReferencesKim, B.H., et al. 2010. Mol. Cancer 9, 36.
      Product Information
      CAS number17392-79-9
      FormYellowish-white powder
      Hill FormulaC₂₆H₃₂N₄O₂S
      Chemical formulaC₂₆H₃₂N₄O₂S
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥99% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      420146-10MG 04055977210675

      Documentation

      JAK3 Inhibitor VIII, NSC114792 - CAS 17392-79-9 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Références bibliographiques

      Aperçu de la référence bibliographique
      Kim, B.H., et al. 2010. Mol. Cancer 9, 36.

      Informations techniques

      Titre
      JAK/STAT Signaling Research Focus
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision22-November-2012 JSW
      Synonyms10,13-Dimethyl-17-(2-(6-sulfanylidene-3H-purin-9-yl)acetyl)-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one, Dimethyl-sulfanylidene-purinyl-acetyl-dodecahydrocyclopenta[a]phenanthren-3-one
      DescriptionA cell-permeable steroidal-purinethione compound that targets JAK3 kinase domain and selectively inhibits JAK3, but not JAK1, JAK2, or TYK2, activity in cell-free immuncomplex kinase assays, and effectively blocks the constitutive Jak3 and STAT5 phosphorylations (complete inhibition at 10 µM) in BaF3-JAK3V674A and BLNK-/- BKO84 culltures. Shown to prevent the JAK3-dependent survival of L540, BaF3-JAK3WT, BaF3-JAK3V674A, and BLNK-/- BKO84 cells in a time- and dose-dependent manner (by 40%, 50%, 57%, and 85%, respectively, after 72 h incubation with 20 µM inhibitor), while exhibiting no effect against the JAK3-independent growth in DU145, HDLM-2, and MDA-MB-468 cultures.
      FormYellowish-white powder
      Intert gas (Yes/No) Packaged under inert gas
      CAS number17392-79-9
      Chemical formulaC₂₆H₃₂N₄O₂S
      Structure formulaStructure formula
      Purity≥99% by HPLC
      SolubilityDMSO (10 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesKim, B.H., et al. 2010. Mol. Cancer 9, 36.