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420123 JNK Inhibitor II, Negative Control - CAS 54642-23-8 - Calbiochem

The JNK Inhibitor II, Negative Control, also referenced under CAS 54642-23-8, controls the biological activity of JNK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: N¹-Methyl-1,9-pyrazoloanthrone

Primary Target: A useful negative control for JNK Inhibitor II (SP600125, Cat. No. 420119)
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420123
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Tableau de caractéristiques principal

CAS #Empirical Formula
54642-23-8C₁₅H₁₀N₂O

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      Description
      OverviewA useful negative control for JNK Inhibitor II (SP600125, Cat. No. 420119). Inhibits JNK2 and JNK3 only at much higher concentrations (IC50 = 18 µM and 24 µM, respectively) compared to SP600125 (IC50 = 40 nM and 90 nM, respectively).
      Catalogue Number420123
      Brand Family Calbiochem®
      SynonymsN¹-Methyl-1,9-pyrazoloanthrone
      References
      ReferencesShin, M., and Boyd, Y.D. 2002. Biochim. Biophys. Acta 1589, 311.
      Bennett, B.L., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 13681.
      Product Information
      CAS number54642-23-8
      ATP CompetitiveY
      FormYellow solid
      Hill FormulaC₁₅H₁₀N₂O
      Chemical formulaC₁₅H₁₀N₂O
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetA useful negative control for JNK Inhibitor II (SP600125, Cat. No. 420119)
      Primary Target IC<sub>50</sub>18 µM and 24 µM against JNK2 and JNK3, respectively
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      420123-1MG 04055977188035

      Documentation

      JNK Inhibitor II, Negative Control - CAS 54642-23-8 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      JNK Inhibitor II, Negative Control - CAS 54642-23-8 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      420123

      Références bibliographiques

      Aperçu de la référence bibliographique
      Shin, M., and Boyd, Y.D. 2002. Biochim. Biophys. Acta 1589, 311.
      Bennett, B.L., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 13681.

      Citations

      Titre
    • Alexandra Thiel, Mira Heinonen, Johanna Rintahaka, Tuija Hallikainen, and Annabrita Hemmes, Dan A. Dixon, Caj Haglund, and Ari Ristimaki. (2006) EXPRESSION OF CYCLOOXYGENASE-2 IS REGULATED BY GSK-3 IN GASTRIC CANCER CELLS. Journal of Biological Chemistry in press,.
      		•
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision13-April-2011 RFH
      SynonymsN¹-Methyl-1,9-pyrazoloanthrone
      DescriptionA useful negative control for JNK Inhibitor II (SP600125, Cat. No. 420119). Inhibits JNK2 and JNK3 only at much higher concentrations (IC50 = 18 µM and 24 µM, respectively) compared to SP600125 (IC50 = 40 nM and 90 nM, respectively).
      FormYellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number54642-23-8
      Chemical formulaC₁₅H₁₀N₂O
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (10 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesShin, M., and Boyd, Y.D. 2002. Biochim. Biophys. Acta 1589, 311.
      Bennett, B.L., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 13681.
      Citation
    • Alexandra Thiel, Mira Heinonen, Johanna Rintahaka, Tuija Hallikainen, and Annabrita Hemmes, Dan A. Dixon, Caj Haglund, and Ari Ristimaki. (2006) EXPRESSION OF CYCLOOXYGENASE-2 IS REGULATED BY GSK-3 IN GASTRIC CANCER CELLS. Journal of Biological Chemistry in press,.
      		•