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505879 L-741,626 - CAS 81226-60-0 - Calbiochem

L-741,626 - CAS 81226-60-0 - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: Dopamine D₂ Receptor Antagonist, L-741,626, L-741626, L741626

Primary Target: D₂
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      Aperçu

      Replacement Information

      Tableau de caractéristiques principal

      CAS #Empirical Formula
      81226-60-0C₂₀H₂₁ClN₂O
      Description
      Overview

      This product has been discontinued.



      Selective dopamine D2 receptor antagonist that is shown to reversibly block agonist-induced activation of GIRK currents. Reported to have a 15-fold selectivity for D2R over D3R in vitro. Inhibition of 3H-spirperone binding to cloned rat Dopamine receptors show the following Ki values: D2R (7.1 nM), D3R (155 nM), D4R (596 nM). Commonly used D2 inhibitor in addiction research.
      Catalogue Number505879
      Brand Family Calbiochem®
      SynonymsDopamine D₂ Receptor Antagonist, L-741,626, L-741626, L741626
      References
      ReferencesGrundt, P. et al. 2007. Bioorg. Med. Chem. Lett. 17, 745.
      Caine, S. B. et al. 2002. J. Neurosci. 22, 2977.
      Pillai, G. et al. 1998. Neuropharmacol. 337, 983.
      Product Information
      CAS number81226-60-0
      FormWhite solid
      Hill FormulaC₂₀H₂₁ClN₂O
      Chemical formulaC₂₀H₂₁ClN₂O
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetD₂
      Primary Target K<sub>i</sub>7.1 nM
      Purity≥99% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      505879 0

      Documentation

      L-741,626 - CAS 81226-60-0 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Références bibliographiques

      Aperçu de la référence bibliographique
      Grundt, P. et al. 2007. Bioorg. Med. Chem. Lett. 17, 745.
      Caine, S. B. et al. 2002. J. Neurosci. 22, 2977.
      Pillai, G. et al. 1998. Neuropharmacol. 337, 983.

      Brochure

      Titre
      New Products Flyer- Feb 2014 - Vol 1
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision20-September-2013 JSW
      SynonymsDopamine D₂ Receptor Antagonist, L-741,626, L-741626, L741626
      DescriptionSelective dopamine D2 receptor antagonist that is shown to reversibly block agonist-induced activation of GIRK currents. Reported to have a 15-fold selectivity for D2R over D3R in vitro. Inhibition of 3H-spirperone binding to cloned rat Dopamine receptors show the following Ki values: D2R (7.1 nM), D3R (155 nM), D4R (596 nM). Commonly used D2 inhibitor in addiction research.
      FormWhite solid
      CAS number81226-60-0
      Chemical formulaC₂₀H₂₁ClN₂O
      Structure formulaStructure formula
      Purity≥99% by HPLC
      SolubilityDMSO
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesGrundt, P. et al. 2007. Bioorg. Med. Chem. Lett. 17, 745.
      Caine, S. B. et al. 2002. J. Neurosci. 22, 2977.
      Pillai, G. et al. 1998. Neuropharmacol. 337, 983.