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437704 Lipoprotein Lipase Activator

Lipoprotein Lipase Activator : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: Diethyl-4-((4-Bromo-2-cyanophenyl)carbamoyl)benzylphosphonate, NO-1886

437704
  
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      Aperçu

      Replacement Information
      Description
      Overview

      This product has been discontinued.



      We apologize for the inconvenience, but we do not currently have an alternative product.





      A cell-permeable benzylphosphonate derivative that selectively induces lipoprotein lipase (LPL) mRNA and protein levels, but does not exhibit PPARα or PPARγ agonistic activities. Lowers serum lipid levels and plasma triglycerides with concomitant elevation in high-density lipoprotein cholesterol (HDL-C) in animal models. Induces fatty acid oxidation related enzymes, lowers free fatty acids (FFA), and minimizes fat accumulation. Also reported to suppress the plasma levels of TNF-α and COX-2 and displays anti-tumor properties.
      Catalogue Number437704
      Brand Family Calbiochem®
      SynonymsDiethyl-4-((4-Bromo-2-cyanophenyl)carbamoyl)benzylphosphonate, NO-1886
      References
      ReferencesNiho, N., et al. 2005. Proc, Natl. Acad. Sci. USA 102, 2970.
      Yin, W., et al. 2004. Pharmacol. Res. 49, 199.
      Doi, M., et al. 2003. Metabolism 52, 1547.
      Kusunoki, M., et al. 2000. Diabetologia 43, 875.
      Tsutsmi, K., et al. 1993. J. Clin. Invest. 92, 411.
      Product Information
      CAS number133208-93-2
      FormWhite solid
      Hill FormulaC₁₉H₂₀BrN₂O₄P
      Chemical formulaC₁₉H₂₀BrN₂O₄P
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      437704 0

      Documentation

      Lipoprotein Lipase Activator Certificats d'analyse

      TitreNuméro de lot
      437704

      Références bibliographiques

      Aperçu de la référence bibliographique
      Niho, N., et al. 2005. Proc, Natl. Acad. Sci. USA 102, 2970.
      Yin, W., et al. 2004. Pharmacol. Res. 49, 199.
      Doi, M., et al. 2003. Metabolism 52, 1547.
      Kusunoki, M., et al. 2000. Diabetologia 43, 875.
      Tsutsmi, K., et al. 1993. J. Clin. Invest. 92, 411.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision06-August-2008 RFH
      SynonymsDiethyl-4-((4-Bromo-2-cyanophenyl)carbamoyl)benzylphosphonate, NO-1886
      DescriptionA cell-permeable benzylphosphonate derivative that selectively induces lipoprotein lipase (LPL) mRNA and protein levels, but does not exhibit PPARα or PPARγ agonistic activities. Lowers serum lipid levels and plasma triglycerides with concomitant elevation in high-density lipoprotein cholesterol (HDL-C) in animal models. Induces fatty acid oxidation related enzymes, lowers free fatty acids (FFA), and minimizes fat accumulation. Also reported to suppress the plasma levels of TNF-α and COX-2 and displays anti-tumor properties.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number133208-93-2
      Chemical formulaC₁₉H₂₀BrN₂O₄P
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (32 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Irritant
      ReferencesNiho, N., et al. 2005. Proc, Natl. Acad. Sci. USA 102, 2970.
      Yin, W., et al. 2004. Pharmacol. Res. 49, 199.
      Doi, M., et al. 2003. Metabolism 52, 1547.
      Kusunoki, M., et al. 2000. Diabetologia 43, 875.
      Tsutsmi, K., et al. 1993. J. Clin. Invest. 92, 411.