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530650 Luciferase Substrate, CycLuc1 - Calbiochem

A synthetic cyclic alkylaminoluciferin with properties superior to D-luciferin. Binds to luciferase with higher affinity.

Luciferase Substrate, CycLuc1 - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.
Primary Target: Luciferase
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      Aperçu

      Replacement Information

      Tableau de caractéristiques principal

      Empirical Formula
      C₁₃H₁₁N₃O₂S₂
      Description
      OverviewA synthetic cyclic alkylaminoluciferin that exhibits properties that are superior to those of D-luciferin. Binds to luciferase with higher affinity and and emits about 5.7-fold more light than aminoluciferin and 3.2-fold more light than D-luciferin. Its superior light output is maintained over a wide range (1-100 µM). Shown to readily cross the blood-brain barrier in mice and provides much improved noninvasive bioluminescence imaging (BLI) of the brain at lower dose when compared to D-luciferin. Yields about 10-fold higher bioluminescent signal than D-luciferin when Luc2 luciferase expressing 4T1 breast cancer cells are implanted into the mammary fat pads of BABL/c mice. A rapid (4-5 min), long-lasting, and steady signal peak is observed following an i.v injection CycLuc1 in mice.

      Please note that the molecular weight for this compound is batch-specific due to variable water content.
      Catalogue Number530650
      Brand Family Calbiochem®
      References
      ReferencesEvans, M., et al. 2014. Nat Methods. 11, 393.
      Reddy, G. R, et al. 2010. J. Am. Chem. Soc. 132, 13586.
      Product Information
      FormYellow powder
      Hill FormulaC₁₃H₁₁N₃O₂S₂
      Chemical formulaC₁₃H₁₁N₃O₂S₂
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetLuciferase
      Purity≥94% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      530650 0

      Documentation

      Luciferase Substrate, CycLuc1 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Luciferase Substrate, CycLuc1 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      530650

      Références bibliographiques

      Aperçu de la référence bibliographique
      Evans, M., et al. 2014. Nat Methods. 11, 393.
      Reddy, G. R, et al. 2010. J. Am. Chem. Soc. 132, 13586.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision15-April-2019 JSW
      DescriptionA synthetic cyclic alkylaminoluciferin that exhibits properties that are superior to those of D-luciferin. Binds to luciferase with higher affinity and and emits about 5.7-fold more light than aminoluciferin and 3.2-fold more light than D-luciferin. Its superior light output is maintained over a wide range (1-100 µM). Shown to readily cross the blood-brain barrier in mice and provides much improved noninvasive bioluminescence imaging (BLI) of the brain at lower dose when compared to D-luciferin. Yields about 10-fold higher bioluminescent signal than D-luciferin when Luc2 luciferase expressing 4T1 breast cancer cells are implanted into the mammary fat pads of BABL/c mice. A rapid (4-5 min), long-lasting, and steady signal peak is observed following an i.v injection CycLuc1 in mice.
      FormYellow powder
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₁₃H₁₁N₃O₂S₂
      Purity≥94% by HPLC
      SolubilityDMSO (100 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesEvans, M., et al. 2014. Nat Methods. 11, 393.
      Reddy, G. R, et al. 2010. J. Am. Chem. Soc. 132, 13586.