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532280 Myeloperoxidase Inhibitor III, HX1 - CAS 1520083-61-7 - Calbiochem

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Synonymes: MPO Inhibitor III, HX1

532280
  
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      Aperçu

      Replacement Information

      Tableau de caractéristiques principal

      CAS #Empirical Formula
      1520083-61-7C₁₄H₁₀F₆N₄O₃
      Description
      Overview

      This product has been discontinued.



      A cell-permeable, trifluoromethyl substituted aromatic hydroxamate compound that acts as a highly potent, selective, mixed type, reversible inhibitor of the chlorination activity of myeloperoxidase (MPO; IC50 = 5 nM). Tightly binds within the active site cavity above the heme and blocks the substrate channel. Displays over 300-fold greater selectivity for MPO when tested against a panel of redox enzymes, including lactoperoxidase (IC50 = 6.3 µM) and thyroid peroxidase (IC50 = 1.59 µM). Blocks the production of hypochlorous acid by human neutrophils (IC50 = 50 nM) and inhibits the formation of NADH bromohydrin (IC50 = 70 nM with 50 µM H2O2 and 10 mM NaBr).

      Please note that the molecular weight for this compound is batch-specific due to variable water content.

      Catalogue Number532280
      Brand Family Calbiochem®
      SynonymsMPO Inhibitor III, HX1
      References
      ReferencesForbes, L. V., et al. 2013. J. Bio. Chem. 288, 36636.
      Product Information
      CAS number1520083-61-7
      FormWhite powder
      Hill FormulaC₁₄H₁₀F₆N₄O₃
      Chemical formulaC₁₄H₁₀F₆N₄O₃
      ReversibleY
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetMPO
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      532280 0

      Documentation

      Myeloperoxidase Inhibitor III, HX1 - CAS 1520083-61-7 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Références bibliographiques

      Aperçu de la référence bibliographique
      Forbes, L. V., et al. 2013. J. Bio. Chem. 288, 36636.

      Brochure

      Titre
      Pathways and Biomarkers of Oxidative Stress

      Informations techniques

      Titre
      White Paper: Further considerations of antibody validation and usage.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision27-January-2015 JSW
      SynonymsMPO Inhibitor III, HX1
      DescriptionA cell-permeable, trifluoromethyl substituted aromatic hydroxamate compound that acts as a highly potent, selective, mixed type, reversible inhibitor of the chlorination activity of myeloperoxidase (MPO; IC50 = 5 nM). Tightly binds within the active site cavity above the heme and blocks the substrate channel. Displays over 300-fold greater selectivity for MPO when tested against a panel of redox enzymes, including lactoperoxidase (IC50 = 6.3 µM) and thyroid peroxidase (IC50 = 1.59 µM). Blocks the production of hypochlorous acid by human neutrophils (IC50 = 50 nM) and inhibits the formation of NADH bromohydrin (IC50 = 70 nM with 50 µM H2O2 and 10 mM NaBr).
      FormWhite powder
      Intert gas (Yes/No) Packaged under inert gas
      CAS number1520083-61-7
      Chemical formulaC₁₄H₁₀F₆N₄O₃
      Purity≥98% by HPLC
      SolubilityDMSO (50 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesForbes, L. V., et al. 2013. J. Bio. Chem. 288, 36636.