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855029 N-Cyclohexylcarbodiimide,N'-methyl polystyrene

Novabiochem®

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.
Nº CAS: 9003-70-7
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855029
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Tableau de caractéristiques principal

CAS #
9003-70-7
Description
Référence855029
Replaces01-64-0211
Famille de marques Novabiochem®
Informations généralesN-Cyclohexylcarbodiimide,N'-methyl polystyrene [1] is an ideal tool for mediating solution phase coupling reactions. Typically, the amine and carboxylic acid are treated with a 2-3 fold excess of resin in DCM or DMF [2, 3]; a slight excess of carboxyl component over amine component is often used to help drive the reaction to completion. As excess acid and urea by-products remain attached to the resin at the end of the reaction, the product can normally be isolated pure by filtration and evaporation of the reaction mixture. Reactions can be accelerated by the addition of auxiliary nucleophiles such as HOBt; these can be removed using polyamine- or TBD-polystyrene. This resin has also been used in conjunction with DMAP to mediate ester formation [4].

The product number for this product was previously 01-64-0211.

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Références bibliographiques
Informations produit
Numéro CAS9003-70-7
Code SH3903 90 90
Image de la formule structuraleImage de la formule structurale
Quality LevelMQ200
Applications
Informations biologiques
Informations physico-chimiques
Dimensions
Informations sur les matériaux
Informations toxicologiques
Informations de sécurité selon le SGH
Classe de stockage10 - 13 Autres liquides ou matières solides
WGKWGK 1 pollue faiblement l'eau
Informations sur la sécurité
Notifications sur l'utilisation du produit
Informations relatives au stockage et à l'expédition
StockageConserver de +2°C à +8°C.
Informations sur l'emballage
Informations sur le transport
Information complémentaire
Caractéristiques
Color (visual)slightly beige to brown
Appearance of substance (visual)beads
Loading (determined by HPLC after reaction of Z-Phe-OH with cyclohexylamine)≥ 1.3 mmol/g
Swelling Volume (in CH₂Cl₂)lot specific result
The polymer matrix is copoly (styrene-2 % DVB), 200 - 400 mesh.

Documentation

N-Cyclohexylcarbodiimide,N'-methyl polystyrene FDS

Titre

Fiche de données de sécurité des matériaux (FDS) 

Citations

Titre
  • [1] G.M Weinshenker, et al. (1988) Org. Synth., Coll. Vol. VI, 951.
  • [2] Y. Guan, et al. (2000) J. Comb. Chem., 2, 297.
  • [3] K. Senton, et al. (2003) J. Comb. Chem., 5, 336.
  • [4] M. Cano, et al. (2002) J. Org. Chem., 67, 129.