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855010 NovaSyn®TGT alcohol resin

Novabiochem®

NovaSyn®TGT alcohol resin : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.
Nº CAS: 478242-36-3
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855010
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Tableau de caractéristiques principal

CAS #
478242-36-3
Description
Référence855010
Replaces01-64-0066
Famille de marques Novabiochem®
Informations généralesNovaSyn® TGT alcohol resin is derived from TG amino resin by acylation with Bayer's 4-carboxytrityl linker [1]. Before use the resin must be converted to the chloride form by heating with AcCl [2, 3] or SOCl2 [4, 5] in toluene. The unstable trityl chloride resin should then be used immediately.

Attachment of α-amino acids is free from enantiomerization, making this support ideal for the immobilization of sensitive residues such as Cys and His.

Iodine oxidation of peptides containing Cys(Trt) occurs with release of the peptide from the resin.

This support is also ideally suited to the synthesis of prolyl peptides as the bulk of the trityl handle prohibits diketopiperazine formation [6].

Cleavage of protected peptide acids from this matrix can be effected by treatment with AcOH/MeOH/DCM [1], 0.5% TFA or HFIP [7].

The product number for this product was previously 01-64-0066.

To obtain a certificate of analysis (CoA) of a lot that begins with the letter "A", please select the option in the right hand menu "Request a COA for Lot#s starting with A".
Références bibliographiques
Informations produit
Numéro CAS478242-36-3
Code SH3903 90 90
Image de la formule structuraleImage de la formule structurale
Quality LevelMQ200
Applications
Informations biologiques
Informations physico-chimiques
Dimensions
Informations sur les matériaux
Informations toxicologiques
Informations de sécurité selon le SGH
Classe de stockage10 - 13 Autres liquides ou matières solides
WGKWGK 1 pollue faiblement l'eau
Informations sur la sécurité
Notifications sur l'utilisation du produit
Informations relatives au stockage et à l'expédition
StockageConserver de +2°C à +8°C.
Informations sur l'emballage
Informations sur le transport
Information complémentaire
Caractéristiques
Color (visual)white to yellow to beige
Appearance of substance (visual)beads
Loading (determined from the substitution of the Fmoc-Leu loaded resin)0.15 - 0.30 mmol/g
Swelling Volume (in CH₂Cl₂)lot specific result
The polymer matrix is NovaSyn TG resin (90 µm).

Documentation

NovaSyn®TGT alcohol resin FDS

Titre

Fiche de données de sécurité des matériaux (FDS) 

Citations

Titre
  • [1] E. Bayer, et al. in 'Peptides, Chemistry, Structure & Biology, Proc. 13th American Peptide Symposium', R. S. Hodges & J. A. Smith (Eds), ESCOM, Leiden, 1994, pp. 156.
  • [2] J. M. J. Frechet, et al. (1975) Tetrahedron Lett., 3055.
  • [3] T. M. Fyles, et al. (1976) Can. J. Chem., 54, 935.
  • [4] A. v. Vliet, et al. in 'Innovation & Perspectives in Solid Phase Synthesis, 2nd International Symposium', R. Epton (Eds), Intercept UK Ltd., Andover, 1992, pp. 475.
  • [5] A. v. Vliet, et al. in 'Peptides 1992, Proc. 22nd European Peptide Symposium', C. H. Schneider & A. N. Eberle (Eds), ESCOM, Leiden, 1993, pp. 279.
  • [6] G. Grübler, et al. in 'Innovation & Perspectives in Solid Phase Synthesis, 3rd International Symposium', R. Epton (Eds), Mayflower Worldwide Ltd., Birmingham, 1994, pp. 517.
  • [7] R. Bollhagen, et al. (1994) J. Chem. Soc., Chem. Commun., 2559.