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505316 PHA-543,613 - CAS 478149-53-0 - Calbiochem

PHA-543,613 - CAS 478149-53-0 - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide, Alpha 7 Nicotinic Acetylcholine Receptor (α7 nAChR) Agonist, PHA-543613

Primary Target: α7 nAChR
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      Aperçu

      Replacement Information

      Tableau de caractéristiques principal

      CAS #Empirical Formula
      478149-53-0C₁₅H₁₇N₃O₂
      Description
      Overview

      This product has been discontinued.



      A potent agonist highly selective for α7 nicotinic acetylcholine receptor (α7 nAChR). Bioavaible admitted orally. Widely used in studies of the functional roles of α7 nAChR in learning and memory, sensory gating, and cognitive functions as well as Schizophrenia and Alzheimer′s disease.
      Catalogue Number505316
      Brand Family Calbiochem®
      SynonymsN-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide, Alpha 7 Nicotinic Acetylcholine Receptor (α7 nAChR) Agonist, PHA-543613
      References
      ReferencesMazurov, A., et al., 2011. J. Med. Chem. 54, 7943.
      Wishka, G., et al., 2006. J. Med. Chem. 49, 4425.
      Faghih, R., et al., 2008. J. Med. Chem. 51, 701.
      Product Information
      CAS number478149-53-0
      FormWhite powder
      Hill FormulaC₁₅H₁₇N₃O₂
      Chemical formulaC₁₅H₁₇N₃O₂
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetα7 nAChR
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      505316 0

      Documentation

      PHA-543,613 - CAS 478149-53-0 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Références bibliographiques

      Aperçu de la référence bibliographique
      Mazurov, A., et al., 2011. J. Med. Chem. 54, 7943.
      Wishka, G., et al., 2006. J. Med. Chem. 49, 4425.
      Faghih, R., et al., 2008. J. Med. Chem. 51, 701.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision17-July-2013 JSW
      SynonymsN-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide, Alpha 7 Nicotinic Acetylcholine Receptor (α7 nAChR) Agonist, PHA-543613
      DescriptionA potent agonist highly selective for α7 nicotinic acetylcholine receptor (α7 nAChR). Bioavaible admitted orally. Widely used in studies of the functional roles of α7 nAChR in learning and memory, sensory gating, and cognitive functions as well as Schizophrenia and Alzheimer′s disease.
      FormWhite powder
      CAS number478149-53-0
      Chemical formulaC₁₅H₁₇N₃O₂
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (20 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesMazurov, A., et al., 2011. J. Med. Chem. 54, 7943.
      Wishka, G., et al., 2006. J. Med. Chem. 49, 4425.
      Faghih, R., et al., 2008. J. Med. Chem. 51, 701.