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532978 PLD2 Inhibitor, ML395 - CAS 1638957-17-1 - Calbiochem

ML395 is a cell permeable, highly potent, selective, and direct allosteric inhibitor of phospholipase D2 (PLD2; IC₅₀ = 360 nM) that exhibits >80-fold selectivity over PLD1.

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Synonymes: Phosppolipase D2 inhibitor, VU0468809, ML-395

Primary Target: PLD2
532978
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Tableau de caractéristiques principal

CAS #Empirical Formula
1638957-17-1C₂₆H₂₉N₅O₂

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      Description
      OverviewA cell permeable, triazaspirone derivative that acts as a highly potent, selective, and direct allosteric inhibitor of phospholipase D2 (PLD2; IC50 = 360 nM in exogenous biochemical assay). Exhibits >80-fold selectivity over phospholipase D1 (PLD1; IC50 = 30 µM). Shown to permeate the blood-brain barrier. Protects A549 cells from multiple strains of influenza virus when cells were pre-treated with this compound. Exhibits excellent DMPK profile (hepatic microsomal clearance = 82.1 ml/min/kg in Sprague-Dawley rats) and conforms to Lipinski's rule and has favorable lipophilicity. Also displays favorable cytochrome P450 profile (CYP3A4 IC50 = 3.9 µM, CYP2D6 IC50 =16.4 µM, CYP1A2 IC50>30 µM, and CYP2C9 IC50>30 µM).

      Please note that the molecular weight for this compound is batch-specific due to variable water content.
      Catalogue Number532978
      Brand Family Calbiochem®
      SynonymsPhosppolipase D2 inhibitor, VU0468809, ML-395
      References
      ReferencesO'Reilly, M.C., et al. 2014. ChemMedChem 9, 2633.
      Product Information
      CAS number1638957-17-1
      FormOff-white solid
      Hill FormulaC₂₆H₂₉N₅O₂
      Chemical formulaC₂₆H₂₉N₅O₂
      ReversibleY
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetPLD2
      Primary Target IC<sub>50</sub>360 nM
      Purity≥97% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C).
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      5.32978.0001 04055977281972

      Documentation

      PLD2 Inhibitor, ML395 - CAS 1638957-17-1 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Références bibliographiques

      Aperçu de la référence bibliographique
      O'Reilly, M.C., et al. 2014. ChemMedChem 9, 2633.

      Informations techniques

      Titre
      Characterization of Estrogen Receptor α Phosphorylation Sites in Breast Cancer Tissue Using the SNAP i.d® 2.0 System
      White Paper: Further considerations of antibody validation and usage.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision17-April-2015 JSW
      SynonymsPhosppolipase D2 inhibitor, VU0468809, ML-395
      DescriptionA cell permeable, triazaspirone derivative that acts as a highly potent, selective, and direct allosteric inhibitor of phospholipase D2 (PLD2; IC50 = 360 nM in exogenous biochemical assay). Exhibits >80-fold selectivity over phospholipase D1 (PLD1; IC50 = 30 µM). Shown to permeate the blood-brain barrier. Protects A549 cells from multiple strains of influenza virus when cells were pre-treated with this compound. Exhibits excellent DMPK profile (hepatic microsomal clearance = 82.1 ml/min/kg in Sprague-Dawley rats) and conforms to Lipinski's rule and has favorable lipophilicity. Also displays favorable cytochrome P450 profile (CYP3A4 IC50 = 3.9 µM, CYP2D6 IC50 =16.4 µM, CYP1A2 IC50>30 µM, and CYP2C9 IC50>30 µM).
      FormOff-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number1638957-17-1
      Chemical formulaC₂₆H₂₉N₅O₂
      Purity≥97% by HPLC
      SolubilityDMSO (50 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C).
      Toxicity Standard Handling
      ReferencesO'Reilly, M.C., et al. 2014. ChemMedChem 9, 2633.