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504772 Prazosin Hydrochloride - CAS 19237-84-4 - Calbiochem

Prazosin hydrochloride, a quinazole derivative, is a very potent and highly selective antagonist for α₁-adrenoceptors.

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Synonymes: 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)piperazine hydrochloride, Furazosin hydrochloride, CP-12299-1, α₁-Adrenoceptor Antagonist, Prazosin Hydrochloride, Furazosin hydrochloride, Deprazolin, Furazosin Hydrochloride, Hypovase, Hypovasole

Primary Target: →₁-adrenoceptors
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      Aperçu

      Replacement Information

      Tableau de caractéristiques principal

      CAS #Empirical Formula
      19237-84-4 C₁₉H₂₁N₅O₄ • HCl
      Description
      OverviewPrazosin hydrochloride, a quinazole derivative, is a very potent and highly selective antagonist for α1-adrenoceptors (affinity for α1 is about 1000-fold greater than for α2 receptors). Mainly used as a clinic vasodilator for blood pressure control without increasing the heart rate or significantly impairing sympathetic functions. Has also been used clinically to treat anxiety, PTSD, and panic disorder. An excellent candidate for research studying brain functions mediated through α1-adrenergic receptors, such as reward, pleasure, aggression, fear, anxiety, and addiction.
      Catalogue Number504772
      Brand Family Calbiochem®
      Synonyms1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)piperazine hydrochloride, Furazosin hydrochloride, CP-12299-1, α₁-Adrenoceptor Antagonist, Prazosin Hydrochloride, Furazosin hydrochloride, Deprazolin, Furazosin Hydrochloride, Hypovase, Hypovasole
      References
      ReferencesPickering,.D., et al. 1990. Eur. J. Pharmacol. 175, 71.
      Mathe, J., et al. 1996. Eur. J. Pharmacol. 309, 1.
      Paul, P., et al. 1999. J. Pharmacol. Exp. Ther. 290, 334.
      Dinh, L., et al. 2009. Neurochem Res 34, 1896.
      Product Information
      CAS number19237-84-4
      FormWhite solid
      Hill Formula C₁₉H₂₁N₅O₄ • HCl
      Chemical formulaC₁₉H₂₁N₅O₄ • HCl
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Primary Target→₁-adrenoceptors
      Primary Target K<sub>i</sub>0.17, 0.26, and 0.07 for →1a, →1b, and →1d adrenoceptor, respectively.
      Purity%ge;99% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 22

      Harmful if swallowed.
      S PhraseS: 22-24/25

      Do not breathe dust.
      Avoid contact with skin and eyes.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Harmful
      Storage +15°C to +30°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      504772 0

      Documentation

      Prazosin Hydrochloride - CAS 19237-84-4 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Références bibliographiques

      Aperçu de la référence bibliographique
      Pickering,.D., et al. 1990. Eur. J. Pharmacol. 175, 71.
      Mathe, J., et al. 1996. Eur. J. Pharmacol. 309, 1.
      Paul, P., et al. 1999. J. Pharmacol. Exp. Ther. 290, 334.
      Dinh, L., et al. 2009. Neurochem Res 34, 1896.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision12-July-2013 JSW
      Synonyms1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)piperazine hydrochloride, Furazosin hydrochloride, CP-12299-1, α₁-Adrenoceptor Antagonist, Prazosin Hydrochloride, Furazosin hydrochloride, Deprazolin, Furazosin Hydrochloride, Hypovase, Hypovasole
      DescriptionPrazosin hydrochloride, a quinazole derivative, is a very potent and highly selective antagonist for α1-adrenoceptors (affinity for α1 is about 1000-fold greater than for α2 receptors). Mainly used as a clinic vasodilator for blood pressure control without increasing the heart rate or significantly impairing sympathetic functions. Has also been used clinically to treat anxiety, PTSD, and panic disorder. An excellent candidate for research studying brain functions mediated through α1-adrenergic receptors, such as reward, pleasure, aggression, fear, anxiety, and addiction.
      FormWhite solid
      CAS number19237-84-4
      Chemical formulaC₁₉H₂₁N₅O₄ • HCl
      Structure formulaStructure formula
      Purity%ge;99% by HPLC
      SolubilityDMSO (25 mM). Slight warming is required for complete solubilization.
      Storage Protect from light
      +15°C to +30°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Harmful
      ReferencesPickering,.D., et al. 1990. Eur. J. Pharmacol. 175, 71.
      Mathe, J., et al. 1996. Eur. J. Pharmacol. 309, 1.
      Paul, P., et al. 1999. J. Pharmacol. Exp. Ther. 290, 334.
      Dinh, L., et al. 2009. Neurochem Res 34, 1896.