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420294 STAT5 Inhibitor II, IQDMA - Calbiochem

The STAT5 Inhibitor II, IQDMA controls the biological activity of STAT5.

STAT5 Inhibitor II, IQDMA - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: N1-(11H-indolo[3,2-c]quinolin-6-yl)-N2,N2-dimethylethane-1,2-diamine

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420294
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Aperçu

Replacement Information

Tableau de caractéristiques principal

Empirical Formula
C₁₉H₂₀N₄

Prix & Disponibilité

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420294-10MG
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      		 10 mg
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      Description
      OverviewA cell-permeable indoloquinoline compound that exhibits anticancer activity and inhibits the growth of A549 lung cancer cells (IC50 = 8 µM), as well as HL-60 (IC50 = 5 µM) and K562 (IC50 = 8 µM) leukemia cells. IQDMA-mediated apoptosis is shown to correlate with a downregulation of STAT5 pathway signaling in HL-60 and K562 cultures, while JNK and p38 signalings are shown to be activated in A549 cells upon IQDMA treatment.
      Catalogue Number420294
      Brand Family Calbiochem®
      SynonymsN1-(11H-indolo[3,2-c]quinolin-6-yl)-N2,N2-dimethylethane-1,2-diamine
      References
      ReferencesSu, J.C., et al. 2009, Life Sci. 85, 505.
      Chien, C.M., et al. 2008, Chem-Biol. Intr. 176, 40.
      Yang, S.H., et al. 2008, J. Biochem. Mol. Tox. 22, 396.
      Product Information
      FormWhite to beige solid
      Hill FormulaC₁₉H₂₀N₄
      Chemical formulaC₁₉H₂₀N₄
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      420294-10MG 04055977210897

      Documentation

      STAT5 Inhibitor II, IQDMA - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      STAT5 Inhibitor II, IQDMA - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      420294

      Références bibliographiques

      Aperçu de la référence bibliographique
      Su, J.C., et al. 2009, Life Sci. 85, 505.
      Chien, C.M., et al. 2008, Chem-Biol. Intr. 176, 40.
      Yang, S.H., et al. 2008, J. Biochem. Mol. Tox. 22, 396.

      Brochure

      Titre
      Pathways and Biomarkers of JAK/STAT Signaling

      Informations techniques

      Titre
      JAK/STAT Signaling Research Focus
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision06-May-2020 JSW
      SynonymsN1-(11H-indolo[3,2-c]quinolin-6-yl)-N2,N2-dimethylethane-1,2-diamine
      DescriptionA cell-permeable indoloquinoline compound that exhibits anticancer activity and inhibits the growth of A549 lung cancer cells (IC50 = 8 µM), as well as HL-60 (IC50 = 5 µM) and K562 (IC50 = 8 µM) leukemia cells. IQDMA-mediated apoptosis is shown to correlate with a downregulation of STAT5 pathway signaling in HL-60 and K562 cultures, while JNK and p38 signalings are shown to be activated in A549 cells upon IQDMA treatment.
      FormWhite to beige solid
      Chemical formulaC₁₉H₂₀N₄
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (50 mg/ml)
      Storage +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesSu, J.C., et al. 2009, Life Sci. 85, 505.
      Chien, C.M., et al. 2008, Chem-Biol. Intr. 176, 40.
      Yang, S.H., et al. 2008, J. Biochem. Mol. Tox. 22, 396.