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681500 WHI-P180

A potent inhibitor of lgE-mediated mast cell responses to allergens in vitro and in vivo.

WHI-P180 : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: 4-(3ʹ-Hydroxyphenyl)amino-6,7-dimethoxyquinazoline

Primary Target: Cdk2
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681500
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Replacement Information

Tableau de caractéristiques principal

CAS #Empirical Formula
211555-08-7C₁₆H₁₅N₃O₃

Prix & Disponibilité

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681500-1MG
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      Description
      OverviewA potent inhibitor of lgE-mediated mast cell responses to allergens in vitro and in vivo. Also inhibits cyclin-dependent kinase 2 (Cdk2; IC50 = 1 µM) by blocking the ATP site.
      Catalogue Number681500
      Brand Family Calbiochem®
      Synonyms4-(3ʹ-Hydroxyphenyl)amino-6,7-dimethoxyquinazoline
      References
      ReferencesShewchuk, L., et al. 2000. J. Med. Chem. 43, 133.
      Chen, C.L., et al. 1999. Pharm. Res. 16, 117.
      Product Information
      CAS number211555-08-7
      ATP CompetitiveN
      FormPale yellow solid
      Hill FormulaC₁₆H₁₅N₃O₃
      Chemical formulaC₁₆H₁₅N₃O₃
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetCdk2
      Primary Target IC<sub>50</sub>1 µM for Cdk2
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      681500-1MG 04055977260687

      Documentation

      WHI-P180 FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      WHI-P180 Certificats d'analyse

      TitreNuméro de lot
      681500

      Références bibliographiques

      Aperçu de la référence bibliographique
      Shewchuk, L., et al. 2000. J. Med. Chem. 43, 133.
      Chen, C.L., et al. 1999. Pharm. Res. 16, 117.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision23-June-2009 RFH
      Synonyms4-(3ʹ-Hydroxyphenyl)amino-6,7-dimethoxyquinazoline
      DescriptionA potent inhibitor of IgE-mediated mast cell responses to allergens in vitro and in vivo. Also inhibits cyclin-dependent kinase 2 (Cdk2; IC50 = 1 µM) by blocking the ATP site.
      FormPale yellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number211555-08-7
      Chemical formulaC₁₆H₁₅N₃O₃
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (50 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesShewchuk, L., et al. 2000. J. Med. Chem. 43, 133.
      Chen, C.L., et al. 1999. Pharm. Res. 16, 117.