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681674 Wnt Pathway Inhibitor XI, CCT036477 - CAS 305372-78-5 - Calbiochem

The Wnt Pathway Inhibitor XI, CCT036477, also referenced under CAS 305372-78-5, controls the biological activity of Wnt Pathway. This small molecule/inhibitor is primarily used for Cancer applications.

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: CCT036477, CRT Inhibitor VI, β-Catenin/Tcf Inhibitor VI

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681674
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Tableau de caractéristiques principal

CAS #Empirical Formula
305372-78-5C₂₁H₁₈ClN₃

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      Description
      OverviewA cell-permeable indole derivative that acts as an inhibitor of Wnt signaling and exhibits an inhibitory effect in a reporter cell line (IC50 = 4.6 µM) and demonstrates growth inhibition in multiple cancer cell lines, not by altering β-catenin accumulation but by blocking transcription at the β-catenin level. Displays reduced expression of Wnt target genes in myc and survivin-luciferase reporter assays, and exhibits in vivo activity by blocking the development of zebrafish at 20 µM and Xenopus embryos at 75 µM.
      Catalogue Number681674
      Brand Family Calbiochem®
      SynonymsCCT036477, CRT Inhibitor VI, β-Catenin/Tcf Inhibitor VI
      References
      ReferencesEwan, K., et al. 2010. Cancer Res. 70, 5963.
      Product Information
      CAS number305372-78-5
      FormOff-white solid
      Hill FormulaC₂₁H₁₈ClN₃
      Chemical formulaC₂₁H₁₈ClN₃
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥95% by 1H NMR
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing recontitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      681674-5MG 04055977225228

      Documentation

      Wnt Pathway Inhibitor XI, CCT036477 - CAS 305372-78-5 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Wnt Pathway Inhibitor XI, CCT036477 - CAS 305372-78-5 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      681674

      Références bibliographiques

      Aperçu de la référence bibliographique
      Ewan, K., et al. 2010. Cancer Res. 70, 5963.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision16-March-2012 JSW
      SynonymsCCT036477, CRT Inhibitor VI, β-Catenin/Tcf Inhibitor VI
      DescriptionA cell-permeable indole derivative that acts as an inhibitor of Wnt signaling and exhibits an inhibitory effect in a reporter cell line (IC50 = 4.6 µM) and demonstrates growth inhibition in multiple cancer cell lines, not by altering β-catenin accumulation but by blocking transcription at the β-catenin level. Displays reduced expression of Wnt target genes in myc and survivin-luciferase reporter assays, and exhibits in vivo activity by blocking the development of zebrafish at 20 µM and Xenopus embryos at 75 µM.
      FormOff-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number305372-78-5
      Chemical formulaC₂₁H₁₈ClN₃
      Structure formulaStructure formula
      Purity≥95% by 1H NMR
      SolubilityDMSO (50 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing recontitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesEwan, K., et al. 2010. Cancer Res. 70, 5963.