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691400 Zebularine - CAS 3690-10-6 - Calbiochem

A cell-permeable chemically stable cytidine analog that displays antitumor properties.

Zebularine - CAS 3690-10-6 - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: 1-(β-D-Ribofuranosyl)-1,2-dihydropyrimidin-2-one, 2-Pyrimidone-1-β-D-riboside

Primary Target: Cytidine deaminase
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      Aperçu

      Replacement Information

      Tableau de caractéristiques principal

      CAS #Empirical Formula
      3690-10-6C₉H₁₂N₂O₅
      Description
      OverviewA cell-permeable chemically stable cytidine analog that displays antitumor properties. Acts as transition state analog inhibitor of cytidine deaminase by binding at the active site as covalent hydrates. Also shown to inhibit DNA methylation and tumor growth both in vitro and in vivo.
      Catalogue Number691400
      Brand Family Calbiochem®
      Synonyms1-(β-D-Ribofuranosyl)-1,2-dihydropyrimidin-2-one, 2-Pyrimidone-1-β-D-riboside
      References
      ReferencesCheng, J.C., et al. 2004. Cancer Cell 6, 151.
      Cheng, J.C., et al. 2003. J. Natl. Cancer Inst. 95, 399.
      Zhou, L., et al. 2002. J. Mol. Biol. 321, 591.
      Barchi, J.J., Jr., et al. 1992. J. Org. Chem. 57, 536.
      Frick, L., et al. 1989. Biochemistry 28, 9423.
      Product Information
      CAS number3690-10-6
      ATP CompetitiveN
      FormOff-white solid
      Hill FormulaC₉H₁₂N₂O₅
      Chemical formulaC₉H₁₂N₂O₅
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetCytidine deaminase
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.


      From Catalog:
      Desc. Field- added "cell-permeable
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      691400 0

      Documentation

      Zebularine - CAS 3690-10-6 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Zebularine - CAS 3690-10-6 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      691400

      Références bibliographiques

      Aperçu de la référence bibliographique
      Cheng, J.C., et al. 2004. Cancer Cell 6, 151.
      Cheng, J.C., et al. 2003. J. Natl. Cancer Inst. 95, 399.
      Zhou, L., et al. 2002. J. Mol. Biol. 321, 591.
      Barchi, J.J., Jr., et al. 1992. J. Org. Chem. 57, 536.
      Frick, L., et al. 1989. Biochemistry 28, 9423.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision16-September-2008 RFH
      Synonyms1-(β-D-Ribofuranosyl)-1,2-dihydropyrimidin-2-one, 2-Pyrimidone-1-β-D-riboside
      DescriptionA chemically stable, cytidine analog that displays anti-tumor properties. Acts as a transition state analog inhibitor of cytidine deaminase by binding to the active size as covalent hydrates. Also shown to inhibit DNA methylation and tumor growth both in vitro and in vivo.
      FormOff-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number3690-10-6
      Chemical formulaC₉H₁₂N₂O₅
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (5 mg/ml) or Methanol (5 mg/ml). Slight warming may be required to achieve complete solubilization.
      Storage +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.


      From Catalog:
      Desc. Field- added "cell-permeable
      Toxicity Standard Handling
      ReferencesCheng, J.C., et al. 2004. Cancer Cell 6, 151.
      Cheng, J.C., et al. 2003. J. Natl. Cancer Inst. 95, 399.
      Zhou, L., et al. 2002. J. Mol. Biol. 321, 591.
      Barchi, J.J., Jr., et al. 1992. J. Org. Chem. 57, 536.
      Frick, L., et al. 1989. Biochemistry 28, 9423.