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506158 p38 MAP Kinase Inhibitor VII, SD-169 - CAS 1670-87-7 - Calbiochem

The p38 MAP Kinase Inhibitor VII, SD-169, also referenced under CAS 1670-87-7, controls the biological activity of p38 MAP Kinase.

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: Indole-5-carboxamide

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506158
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Tableau de caractéristiques principal

CAS #Empirical Formula
1670-87-7C₉H₈N₂O

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506158-10MG
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      		 Ampoule plast. 10 mg
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      Description
      OverviewA cell-permeable indole compound that acts as a potent, ATP-competitive, and isozyme-selective p38α MAP kinase inhibitor (IC50 = 3.2 nM). It inhibits p38β only at much higher concentrations (IC50 = 122 nM) and exhibits little activity against p38γ, ERK2, JNK-1, or MAPKAPK-2 even at concentrations as high as 50 µM. When administered to NOD mice via food intake in vivo, SD-169 is shown to prevent the development of type 1 diabetes in prediabetic mice and display therapeutic efficacy in treating animals already in mild and moderate hyperglycemic states.
      Catalogue Number506158
      Brand Family Calbiochem®
      SynonymsIndole-5-carboxamide
      References
      ReferencesMedicherla, S., et al. 2006. J. Pharmacol. Exp. Ther. 318, 99.
      Product Information
      CAS number1670-87-7
      FormOff-white solid
      Hill FormulaC₉H₈N₂O
      Chemical formulaC₉H₈N₂O
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥97% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 22-36/37/38

      Harmful if swallowed.
      Irritating to eyes, respiratory system and skin.
      S PhraseS: 26-36-45

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      506158-10MG 04055977272284

      Documentation

      p38 MAP Kinase Inhibitor VII, SD-169 - CAS 1670-87-7 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      p38 MAP Kinase Inhibitor VII, SD-169 - CAS 1670-87-7 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      506158

      Références bibliographiques

      Aperçu de la référence bibliographique
      Medicherla, S., et al. 2006. J. Pharmacol. Exp. Ther. 318, 99.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision18-March-2009 RFH
      SynonymsIndole-5-carboxamide
      DescriptionA cell-permeable indole compound that acts as a potent, ATP-competitive, and isozyme-selective p38α MAP kinase inhibitor (IC50 = 3.2 nM). It inhibits p38β only at much higher concentrations (IC50 = 122 nM) and exhibits little activity against p38γ, ERK2, JNK-1, or MAPKAPK-2 even at concentrations as high as 50 µM. When administered to NOD mice via food intake in vivo, SD-169 is shown to prevent the development of type 1 diabetes in prediabetic mice and display therapeutic efficacy in treating animals already in mild and moderate hyperglycemic states.
      FormOff-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number1670-87-7
      Chemical formulaC₉H₈N₂O
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (10 mg/ml) or H2O (1 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Harmful
      ReferencesMedicherla, S., et al. 2006. J. Pharmacol. Exp. Ther. 318, 99.