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504376 RS 102895 hydrochloride - CAS 300815-41-2 - Calbiochem

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Synonymes: 1ʹ-[2-[4-(Trifluoromethyl)phenyl]ethyl]-spiro[4H-3,1-benzoxazine-4,4ʹ-piperidin]-2(1H)-one hydrochloride, RS 102895, RS102895

Primary Target: CCR2
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      Aperçu

      Replacement Information

      Tableau de caractéristiques principal

      CAS #Empirical Formula
      300815-41-2C₂₁H₂₁F₃N₂O₂•HCl
      Description
      Overview

      This product has been discontinued.



      A selective antagonist for CCR2 receptors (IC50 = 0.36 and 17.8 µM for CCR2b and CCR1 receptors, respectively). Blocks monocyte chemoattractant protein-1 induced calcium influx and chemotaxis (IC50 = 32 nM and 1.7 µM respectively). A potential anti-inflammatory therapeutic agent by Inhibiting α1A, α1D and 5-HT1A receptors.
      Catalogue Number504376
      Brand Family Calbiochem®
      Synonyms1ʹ-[2-[4-(Trifluoromethyl)phenyl]ethyl]-spiro[4H-3,1-benzoxazine-4,4ʹ-piperidin]-2(1H)-one hydrochloride, RS 102895, RS102895
      References
      ReferencesLee, Y., 2010. Magnetic Resonance in Medicine. 64, 72.
      Clark, R.D., et al. 1983. J. Med. Chem. 26, 657.
      Mirzadegan, T., et al. 2000. J. Biol. Chem. 275, 5562.
      Mitchell, L., et al. 2012. Int. Immunopharmacol. 15, 357.
      Product Information
      CAS number300815-41-2
      FormOff-white powder
      Hill FormulaC₂₁H₂₁F₃N₂O₂•HCl
      Chemical formulaC₂₁H₂₁F₃N₂O₂•HCl
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetCCR2
      Primary Target IC<sub>50</sub>0.36 and 17.8 µM for human recombinant CCR2b and CCR1 receptors, respectively.
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +15°C to +30°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      504376 0

      Documentation

      Références bibliographiques

      Aperçu de la référence bibliographique
      Lee, Y., 2010. Magnetic Resonance in Medicine. 64, 72.
      Clark, R.D., et al. 1983. J. Med. Chem. 26, 657.
      Mirzadegan, T., et al. 2000. J. Biol. Chem. 275, 5562.
      Mitchell, L., et al. 2012. Int. Immunopharmacol. 15, 357.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision28-June-2013 JSW
      Synonyms1ʹ-[2-[4-(Trifluoromethyl)phenyl]ethyl]-spiro[4H-3,1-benzoxazine-4,4ʹ-piperidin]-2(1H)-one hydrochloride, RS 102895, RS102895
      DescriptionA selective antagonist for CCR2 receptors (IC50 = 0.36 and 17.8 µM for CCR2b and CCR1 receptors, respectively). Blocks monocyte chemoattractant protein-1 induced calcium influx and chemotaxis (IC50 = 32 nM and 1.7 µM respectively). A potential anti-inflammatory therapeutic agent by Inhibiting α1A, α1D and 5-HT1A receptors.
      FormOff-white powder
      CAS number300815-41-2
      Chemical formulaC₂₁H₂₁F₃N₂O₂•HCl
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (10 mg/ml)
      Storage Protect from light
      +15°C to +30°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesLee, Y., 2010. Magnetic Resonance in Medicine. 64, 72.
      Clark, R.D., et al. 1983. J. Med. Chem. 26, 657.
      Mirzadegan, T., et al. 2000. J. Biol. Chem. 275, 5562.
      Mitchell, L., et al. 2012. Int. Immunopharmacol. 15, 357.

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