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  • Mitochondrial Dysfunction | Life Science Research | Merck

    Mitochondria responsible for generating ATP, but they act as sensors of cellular distress, and are the first parts of the cell to send and respond to cell death signals. Explore how mitochondrial dysfunction affects the aging process in Hallmarks of aging.
  • Deregulated Nutrient Sensing | Life Science Research | Merck

    Organisms depend on multiple nutrient sensing pathways to make sure that the cells and tissue obtain just the right amount of necessary nutrients. Metabolic activities can put stress on our cells. Too much activity, and changes in nutrient availability and composition cause cells to age faster.
  • Hallmarks of Aging | Life Science Research | Merck

    The Hallmarks of Aging are rigorously researched phenomena that directly influence aging. Aging is the primary risk factor for major human pathologies, including cancer, diabetes, cardiovascular disorders, and neurodegenerative diseases. The 9 hallmarks include Genomic instability, Telomere attrition, Epigenetic alterations, Loss of proteostasis, Deregulated nutrient sensing, Mitochondrial dysfunction, Cellular senescence, Stem cell exhaustion, Altered intercellular communication.
  • Cell Cycle | Life Science Research | Merck

    Cell cycle, or the process of cell growth and duplication, is the regulatory point for proliferation and development of multicellular organisms. Nuclear signaling controls most checkpoints of the cell cycle, and is in turn regulated by chromatin structure.